ROSALIND ELSIE FRANKLIN

25 July 1920 – 16 April 1958

Chemist & X-ray Crystallographer

Pioneering English chemist and X-ray crystallographer whose work was central to understanding the molecular structures of DNA, RNA, viruses, coal, and graphite. Her X-ray diffraction images of DNA, particularly Photo 51, provided crucial evidence for the double helix structure. A meticulous experimentalist who made lasting contributions to molecular biology and virology, her research on viruses at Birkbeck College established fundamental principles still relevant today.

Education

1942 – 1945

PhD in Physical Chemistry

University of Cambridge

Thesis: "The physical chemistry of solid organic colloids with special reference to coal"

1938 – 1941

Natural Sciences Tripos

Newnham College, Cambridge

Graduated with Second-Class Honours in Chemistry. Awarded research fellowship upon completion.

1931 – 1938

Secondary Education

St Paul's Girls' School, London

Excelled in science, Latin, and sports. Passed matriculation with six distinctions, winning a university scholarship.

Professional Experience

1953 – 1958

Research Associate / Senior Scientist

Birkbeck College, University of London

Led Agricultural Research Council group studying viral structures. Conducted pioneering X-ray crystallography research on tobacco mosaic virus (TMV), RNA viruses, and polio virus. Supervised PhD students and post-doctoral researchers including Aaron Klug and Kenneth Holmes.

1951 – 1953

Research Associate

King's College London – MRC Biophysics Unit

Conducted X-ray diffraction studies of DNA fibres. Discovered the two forms of DNA (A and B). Produced Photo 51, the landmark X-ray diffraction image that provided key evidence for DNA's helical structure. Demonstrated that phosphate groups lie on the outside of the DNA molecule.

1947 – 1950

Chercheur (Postdoctoral Researcher)

Laboratoire Central des Services Chimiques de l'État, Paris

Trained under Jacques Mering in X-ray crystallography techniques applied to amorphous substances. Studied carbon structures and the transformation of coal to graphite. Coined the terms "graphitising" and "non-graphitising carbon".

1942 – 1946

Assistant Research Officer

British Coal Utilisation Research Association (BCURA)

Studied the porosity and microstructure of coal using helium density measurements. Developed methods to classify coals and predict their performance for fuel and gas mask production. Research contributed to wartime efforts.

Key Achievements

Photo 51

Supervised the production of the famous X-ray diffraction photograph that provided crucial evidence for DNA's double helical structure.

DNA Forms

First to discover and characterise the A and B forms of DNA, identifying critical structural parameters.

TMV Structure

Determined that tobacco mosaic virus particles are uniform in length and that RNA is wound along the inner surface of the hollow virus.

Carbon Science

Pioneered understanding of coal microstructure and coined terminology still used in carbon chemistry.

Selected Publications

Molecular Configuration in Sodium Thymonucleate (1953)

Franklin, R.E. & Gosling, R.G. – Nature, 171, 740-741

Evidence for 2-Chain Helix in Crystalline Structure of Sodium Deoxyribonucleate (1953)

Franklin, R.E. & Gosling, R.G. – Nature, 172, 156-157

Structure of Tobacco Mosaic Virus (1955)

Franklin, R.E. – Nature, 175, 379-381

Location of the Ribonucleic Acid in the Tobacco Mosaic Virus Particle (1956)

Franklin, R.E. – Nature, 177, 928-930

Technical Expertise

X-ray Crystallography X-ray Diffraction Physical Chemistry Patterson Function Analysis Molecular Structure Determination Coal & Carbon Chemistry Virology Microscopy

Languages

English
Native
French
Fluent
German
Proficient

Honours & Legacy

• Turner & Newall Research Fellowship (1950–1953)

• Agricultural Research Council Senior Scientist grant (1954–1958)

• U.S. National Institutes of Health grant – largest ever received at Birkbeck (1957)

• Royal Society Rosalind Franklin Award established in her honour (2003)

• Asteroid 9241 Rosfranklin named after her (1997)

• Franklin–Wilkins Building at King's College London (2000)

• Rosalind Franklin University of Medicine and Science, Chicago (2004)

• English Heritage Blue Plaque, Drayton Gardens, London (1992)